Nostr notes by ostermayer

Halt and Catch Fire test post from a nostr project i will release ...

2026-05-19T19:35:10+02:00

Halt and Catch Fire

test post from a nostr project i will release soon https://unstack.io/halt-and-catch-fire

legalzoom is on ☠️ watch. i used to pay for business ...

2026-05-17T03:35:14+02:00

legalzoom is on ☠️ watch. i used to pay for business compliance package that helped me know when various state and federal requirements were due.

with a few scrapes of federal and state websites your bot becomes an always on compliance department

so much of the web is being blocked off from bots because it is ...

2026-05-13T15:06:02+02:00

so much of the web is being blocked off from bots because it is based on attention and advertising and lock in platform metrics. bots don't click on ads and they have no platform loyalty. a bot's measure of success is task completion.

any company selling attention is now on death watch.

💀💀💀💀

ps: firecrawl allows for bypass of most bot gates

people are getting sick... and when sick they produce fragments ...

2026-05-12T16:35:00+02:00

In reply to nevent1q…adc3
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people are getting sick... and when sick they produce fragments that overlap from their sick cells

how they got sick is the real question and was it exposure to poor sanitation or a self replicating viral genome? (that's what i am asking)

for anyone concerned about hantavirus (andes variant) here is ...

2026-05-11T19:33:53+02:00

for anyone concerned about hantavirus (andes variant) here is what is actually happening:

people are getting sick with similar symptoms and when we sequence a mixture of their their genes plus tissue that supposedly has the virus, we see similar genetic sequences.

we extrapolate that there is a full viral genome in that sample but it is all just guess work inference.

1. starting material is a mixture of viral fragments and host material

2. there is no well person sampled as a control just sick people

3. they are not reading one full virus molecule from start to finish they take fragments, without directly knowing their full molecular origin, broke those reads into even smaller overlapping substrings called k-mers, and used those k-mers to reconstruct a longer sequence.

4. none of it proves the existence of a full sample in the mixture taken from a patient.

5. reconstructed genome is not the same thing as a directly observed complete viral molecule.

if you drink diet soda put all your effort into stopping ...

2026-05-10T00:22:16+02:00

if you drink diet soda put all your effort into stopping

Mossavar-Rahmani Y, Kamensky V, Manson JE, et al. “Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women’s Health Initiative.” Stroke, February 14, 2019. DOI: 10.1161/STROKEAHA.118.023100

The cohort was 81,714 postmenopausal women aged 50–79 from the Women’s Health Initiative Observational Study, with a mean follow-up of 11.9 years

Compared with women drinking fewer than 1 such beverage per week, those consuming 2+ artificially sweetened drinks per day had a 23% higher risk of any stroke and a 31% higher risk of ischemic stroke from clotting in small brain blood vessels

They were also 29% more likely to develop coronary heart disease and had 16% all cause mortality

this is an observational study so it is very possible that people drinking diet soda have some other confounder in common causing these issue or it is the ingredients in the soda....

it's very easy to have open claw act as your real estate ...

2026-05-09T00:05:00+02:00

it's very easy to have open claw act as your real estate agent.

all housing listings are public and can be crawled from listing sites.

You give the bot your criteria for a house -- you give it a price range and you even give it some other information you want such as geography, close to parks, trails brick vs stone materials, school district etc etc.

I find the real utility of claw happens when you give your bot an email account (don't use Gmail. they are very aggressive at blocking bots)

Instruct your bot to also dig up historic pricing and comparable sales in the same zip so you get real market pricing. The bot should get the listing agent contact for each house and then send you an email weekly with its research.

Call the listing agent to schedule a walkthrough, then as you navigate the buying process use your bot so you can learn when you need to do each part of the buying process and make offers with market research backing your offer.

bye bye real estate agent fee of 3-6%

unfortunately all the good educational-entertainment content for ...

2026-05-03T19:36:16+02:00

unfortunately all the good educational-entertainment content for kids is on youtube these days.

using youtube means using their algorithm and perpetual recommendation engines where kids never have to stop watching which is obviously bad.

to solve this problem our kids wrote down the list of shows they want to watch and get new episodes.

open claw using a naming script, yt-dlp, and scheduled tasks to download all episodes from their channels in nice folders that plex can read. openclaw checks weekly for new episodes and gets them.

kids now have advertising free plex to watch their favorite channels.

i'm simply saying that truth = empiric reality irrespective ...

2026-04-29T03:09:46+02:00

In reply to nevent1q…66pf
_________________________

i'm simply saying that truth = empiric reality irrespective of the source.

over and over again, I keep hearing many "elites" ...

2026-04-28T23:54:06+02:00

over and over again, I keep hearing many "elites" complaining that they don't know what is and is not authentically human (because of AI).

This is really almost irrelevant to humanity. Never do we care what is authentic or inauthentic

if a computer program tells you something that is true and a human tells you something that is false which one is more important? the authentically human falsehood or the truth?

truth is the pursuit and the medium which it's conveyed is irrelevant

judge everything whether AI generated or human generated under the same standard

your colon cancer risk (and probabaly other cancer risks) are a ...

2026-04-25T13:44:14+02:00

your colon cancer risk (and probabaly other cancer risks) are a product of your microbiome diversity https://aacrjournals.org/cancerres/article/86/7_Supplement/3993/779640/Abstract-3993-Artificial-intelligence-integrated. sticking with my thesis that we create cancer not through our genetic risk but from the environmental impact on our genetics.

Colorectal cancer rates in adults under 50 have been rising about 3% per year

High-fructose corn syrup and pesticides disrupt the gut microbiome

When fructose (especially high high-fructose corn syrup intake) exceeds what the small intestine can absorb (roughly a daily soda’s worth), fructose spills into the colon

Glyphosate and related agricultural chemicals act like low-dose antibiotics on gut bacteria. They preferentially knock out protective species (Lactobacillus, Bifidobacterium) while sparing pro-inflammatory ones, reducing production of butyrate and other short-chain fatty acids that normally protect the colon lining.

Human genetics haven’t changed in 30 years, but the microbiome of someone born in 1990 has been marinating in fructose and pesticide residue since infancy in a way someone born in 1950 never was. If the microbiome is the mediator between modern exposures and tumor biology (as this study suggests) it helps explain why a cancer that used to belong to grandparents is now showing up in their grandchildren.

had openclaw with opus 4.7 create a book recommendation engine ...

2026-04-22T03:40:55+02:00

had openclaw with opus 4.7 create a book recommendation engine based on my prior likes and dislikes across 100 books. its first recommendation "red mars" by kim stanley robinson.

so far excellent.

conversation with a friend today: Friend: Dude, have you heard of ...

2026-04-21T02:31:59+02:00

conversation with a friend today:

Friend: Dude, have you heard of STRC!?

Me: Yea

Friend: It's incredible, as long as MSTR can sell their shares I can earn 11%

Me: Why can they keep selling shares?

Friend: Because they are backed by bitcoin.

Me: So as long as bitcoin goes up long term you get 11% forever.

Friend: Yeah!

Me: So why not just buy bitcoin like Saylor?

Friend: 🤔

most people afraid of raw milk are not afraid to eat parmigiano ...

2026-04-18T19:29:39+02:00

most people afraid of raw milk are not afraid to eat parmigiano reggiano cheese

"Insulin resistance" is one of the most used terms in ...

2026-04-18T18:36:31+02:00

"Insulin resistance" is one of the most used terms in medicine and also one of the least precise

When we say "insulin resistance," we're treating it like a single thing.

Insulin does dozens of things in your body. In any given tissue, some insulin-signaling pathways can be impaired while others remain intact.

In the liver: hyperinsulinemia drives lipogenesis (making fat) while simultaneously failing to suppress gluconeogenesis (making glucose).

The same hormone in the same organ creates two dysfunctional outcomes.

In skeletal muscle when fat builds up inside the muscle cells this then blocks the signal insulin uses to tell your muscles ", take in this sugar from the blood." This happens before liver dysfunction

In your fat tissue, the problem is basically chronic, low-grade inflammation. When fat cells get overloaded, your immune system treats them almost like an injury and prevents insulin from appropriately releasing fat. Fat cells keep storing sugars as fat but slowly leak the fatty acids back out into the blood even when insulin is high.

In the brain, when insulin reaches neurons, it helps tell your brain:
"You've eaten you can stop feeling hungry now". The hypothalamus controls this and still gets the signal but can't pass it along properly due to PI3K signaling impairment.

In all cases, insulin is the messenger molecule and still gets to its destination properly but all other mechanisms that originate from the insulin signal become dysfunctional.

https://pubmed.ncbi.nlm.nih.gov/10903330/
https://pubmed.ncbi.nlm.nih.gov/24281010/

https://pubmed.ncbi.nlm.nih.gov/22385956/

Modern medicine only treats insulin resistance as a way to control blood sugar and ignore all the other organs which are affected due to their chronically inflamed and dysfunctional state.

ha! call me old-fashioned. I still prefer a human written text.

2026-04-12T14:53:20+02:00

In reply to nevent1q…j5up
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ha! call me old-fashioned. I still prefer a human written text.

not sure the audiobook industry has much future. now i just have ...

2026-04-12T14:46:42+02:00

not sure the audiobook industry has much future. now i just have a llm powered voice system read me epubs.

Nostr event nevent1qqs90k5gwje6f6gjj3g0k9nhhps2zwq3umwcpxr064l3xtzhpkfdwcgzyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58ukq6lzd

2026-04-10T04:37:36+02:00

https://www.weizmann.ac.il/immunology/elinav/sites/immunology.elinav/files/2022-06/Artificial%20sweeteners%20induce%20glucose%20intolerance%20by%20altering%20the%20gut%20microbiota.pdf

Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 514(7521), 181–186

saccharin, sucralose, aspartame, and acesulfame-K disrupt the gut microbiome by reducing beneficial bacteria such as Lactobacillus and Bifidobacterium

https://pmc.ncbi.nlm.nih.gov/articles/PMC11501561/

gut dysbiosis messes with production of short-chain fatty acids, which are critical for healthy lipid and glucose metabolism

point me to where i can read the papers on this

2026-04-07T14:51:24+02:00

In reply to nevent1q…5l2w
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point me to where i can read the papers on this

but they can calculate the degree of interaction from the moon on ...

2026-04-07T14:31:09+02:00

In reply to nevent1q…mchf
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but they can calculate the degree of interaction from the moon on the craft right? otherwise how would they do this maneuver?

how do we know it is bending spacetime and now attracting ? ...

2026-04-07T14:23:32+02:00

In reply to nevent1q…s23p
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how do we know it is bending spacetime and now attracting ? isn't this pulling of smaller objects towards a larger object what we call gravity?

i'm still confused because the moon is exerting or causing a ...

2026-04-07T14:22:22+02:00

In reply to nevent1q…mchf
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i'm still confused because the moon is exerting or causing a force on smaller bodies since people are pulled towards the surface and bodies are pulled around it.

isn't this force what we call gravity?

explain this to me like i am 5. isn't the gravitational pull ...

2026-04-07T14:11:29+02:00

In reply to nevent1q…ac67
_________________________

explain this to me like i am 5.

isn't the gravitational pull from the moon as the artemis gets close to the moon what alters the path as the craft changes trajectory around the moon?

perhaps all the "we can't pass through the van allen ...

2026-04-07T14:03:36+02:00

perhaps all the "we can't pass through the van allen belts without dying " conspiracies will now admit they were incorrect.

quoting
nevent1q…s628
Artemis II is not just going "to the Moon," but rather traveling to meet it at an exact point in space.

It’s all about orbital mechanics.

our genetics are very stable. we don't produce mutants and ...

2026-04-07T13:55:33+02:00

our genetics are very stable. we don't produce mutants and evolve into new species rapidly.

if you see a disease like cancer incidence increasing it isn't because of genetics. people frequently say they just got unlucky when they get cancer.

we give ourselves cancer.

cancer grows in metabolic dysfunction. we eat ourselves into cancer. we sit ourselves into cancer. we hide inside the caves of our house into cancer.

for most cancers, unfortunately we only have ourselves to blame and that is incredibly uncomfortable to think about and why we spend so much time and money finding molecular markers for malignancy that get turned on during our times of metabolic dysfunction.

you've probably had your HDL cholesterol measured. your ...

2026-04-07T00:23:46+02:00

you've probably had your HDL cholesterol measured. your doctor told you higher is better. 60, 70, 80 — good numbers.

here's the problem: HDL cholesterol concentration is a poor proxy for HDL function.

HDL's job is reverse cholesterol transport — pulling cholesterol out of peripheral tissues and delivering it to the liver for excretion. That's the cardioprotective mechanism. But a high HDL-C number doesn't tell you whether your HDL is actually functioning.

Oxidation to apolipoprotein A-I (apo A-I), HDL's main protein, impairs its ability to interact with cholesterol transporters (ABCA1, ABCG1).

Dysfunctional HDL can actually promote atherosclerosis.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11432852/

the studies bear this out: raising HDL-C with drugs doesn't reduce cardiovascular events. torcetrapib raised HDL-C significantly and increased mortality. niacin raises HDL-C but adds no cardiovascular benefit. because the number went up but the function didn't.

the emerging measurement is cholesterol efflux capacity (CEC) — how well does your HDL actually pull cholesterol out of cells? that predicts cardiovascular risk better than the raw number.

The same thing destroying the body: oxidative stress, chronic inflammation, insulin resistance are the same things impairing HDL function

if your HDL is 70 but you're metabolically inflamed, your HDL number is meaningless. more useful is you pCEC score (predicted cholesterol efflux capacity)

yes https://pubmed.ncbi.nlm.nih.gov/17928824/ 240,000 people, 48 ...

2026-04-06T14:02:25+02:00

In reply to nevent1q…0pdg
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yes https://pubmed.ncbi.nlm.nih.gov/17928824/ 240,000 people, 48 years of follow-up--found that fructose intake was independently associated with increased kidney stone risk

non-fructose carbohydrates were not

Your cells have an energy sensor called AMPK. When it's ...

2026-04-06T13:53:51+02:00

Your cells have an energy sensor called AMPK. When it's active, you burn fuel efficiently. When it's suppressed, you store fat and your liver pumps out glucose.

Uric acid suppresses AMPK. That means elevated uric acid isn't just a byproduct of metabolic disease — it may be driving it.

This is why high fructose corn syrup and fructose added into foods are uniquely damaging. Unlike glucose, which is metabolized in a tightly regulated way, fructose is processed by the liver roughly 10x faster, with no feedback controls slowing it down.

That rapid metabolism burns through ATP so quickly that the leftover byproducts get converted into uric acid. Worse, the uric acid then amplifies fructokinase — the very enzyme that processes fructose — creating a vicious cycle where each dose sensitizes your liver to the next one.

So the chain is: high fructose corn syrup → ATP depletion → uric acid → AMPK suppressed → insulin resistance, fat storage, and excess glucose production.

The problem was never the sugar per se. It's the uric acid it leaves behind.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4101654/

Nostr event nevent1qqs94nejzn9wz757uarywkmsm4qkswvzgjcd69qrlujfaug0sr3dnmczyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58u2wr0qw

2026-04-02T12:47:34+02:00

the hardest thing to do is shatter your own ego

nothing is happening on any app. It's all happening in the ...

2026-03-30T17:33:49+02:00

In reply to nevent1q…haye
_________________________

nothing is happening on any app. It's all happening in the real world.

there are countless reports of people not burning at all or very ...

2026-03-30T00:54:34+02:00

there are countless reports of people not burning at all or very little when cutting seed oils out of their diet. how could this be?

my hypothesis:

Linoleic acid (the main fatty acid in seed oils) is bacteriostatic and bactericidal (deadly) to small intestinal lactobacillus
https://elifesciences.org/articles/32581

Lactobacillus johnsonii helps stabilize the skin’s resilience to UV damage
https://jddonline.com/articles/exploring-gut-microbiomes-role-in-drug-induced-photosensitivity-need-deeper-investigation-S1545961625P8844X/

so if disruption of gut flora by excessive pufa and linoleic acid causes a loss of the gut's protective effects on the skin, then seed oils could very well contribute to ease of sunburning

when you think about biology from first principle and you learn ...

2026-03-29T14:23:01+02:00

when you think about biology from first principle and you learn that almost 9% of variants are as a result of in silicon processing of base pairs you begin to wonder if our induction of the sub microscopic world is correct

https://pubmed.ncbi.nlm.nih.gov/33822878/

Nostr event nevent1qqsf0u7dzv4deznp0tvgeawch2c7hj09rxdj6x4g0vak5tszwz93x5gzyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58ufdwnn8

2026-03-28T13:45:13+01:00

https://pubmed.ncbi.nlm.nih.gov/19887582/

quoting
nevent1q…4y0g
https://pmc.ncbi.nlm.nih.gov/articles/PMC1934492/

your body needs cholesterol for cellular health and there is an inverse relationship with cancer and low ldl.

more cancer incidence with low ldl

https://pmc.ncbi.nlm.nih.gov/articles/PMC1934492/ your body needs ...

2026-03-28T13:43:59+01:00

https://pmc.ncbi.nlm.nih.gov/articles/PMC1934492/

your body needs cholesterol for cellular health and there is an inverse relationship with cancer and low ldl.

more cancer incidence with low ldl

https://www.loom.com/share/5c815e0d1d7a416eb2ae7fa2c05e4bec The ...

2026-03-27T08:59:13+01:00

https://www.loom.com/share/5c815e0d1d7a416eb2ae7fa2c05e4bec

The Case for Bitcoin in Healthcare April 8 in Nashville

imagine there was an environmental thing where intermittent ...

2026-03-25T12:50:04+01:00

imagine there was an environmental thing where
intermittent exposure increased cancer risk but continuous exposure was not associated (and maybe inversely associated) with cancer risk.

what would you conclude? that you should avoid it or spend as much time around it as possible?

that thing is sun

https://pmc.ncbi.nlm.nih.gov/articles/PMC3960350/

if you have a ton of data, personal or business there is no ...

2026-03-22T08:52:51+01:00

if you have a ton of data, personal or business there is no reason you don't build your own RAG system. it is very very cheap and gives you universal personal search.

if you want to have the motivation to find truth there is no ...

2026-03-22T07:10:40+01:00

In reply to nevent1q…yhlk
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if you want to have the motivation to find truth there is no greater impetus than being frustrated with no knowing a video is true or false...sounds like great motivation for a creative solution

feynman on new ideas: you may feel overwhelmed and just want some ...

2026-03-22T05:07:07+01:00

feynman on new ideas:

you may feel overwhelmed and just want some peace to sit and come up with something wonderful...but there's a better chance that the stress and chaos is what you need for your good idea to take shape

best way to get that chaos and questioning everyday is to just have some kids. soon you will have more ideas than you have time.

k2 with your vitamin d otherwise things will get worse. eat some ...

2026-03-22T04:50:53+01:00

In reply to nevent1q…5fdc
_________________________

k2 with your vitamin d otherwise things will get worse.

eat some liver

ketosis is a survival mechanism, it is not a physiologically ...

2026-03-22T04:44:31+01:00

ketosis is a survival mechanism, it is not a physiologically normal way to live for weeks on end.

The only problem with peer review is the fact almost all studies ...

2026-03-18T18:18:02+01:00

The only problem with peer review is the fact almost all studies keep their raw data private --the peer reviewers rarely see the data and when the study is published, the data remains private.

there's no need for peer review if every study just publishes raw data -- then anyone can evaluate whenever they want

compared to a zerohedge feed ...

2026-03-18T01:13:08+01:00

In reply to nevent1q…mx8c
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compared to a zerohedge feed

looks like this. if each item within the block was the item ...

2026-03-18T01:06:09+01:00

In reply to nevent1q…mx8c
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looks like this. if each item within the block was the item headline would be nicer in an rss reader so i could just click on the news item directly as a feed entry

news articles need individual rss headlines for ease of scrolling ...

2026-03-18T00:29:22+01:00

In reply to nevent1q…fkav
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news articles need individual rss headlines for ease of scrolling through headlines in an rss reader so you can click on only those of interest. right now everything in a block headline.

yeah i have a tough time with the earth, since we can obviously ...

2026-03-17T22:28:33+01:00

In reply to nevent1q…qpdc
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yeah i have a tough time with the earth, since we can obviously photograph different "sides" of the earth and spherical navigation (flying in a curve from chicago to shanghai) works...

definitely viruses-- but help me understand why earth from space? ...

2026-03-17T22:13:22+01:00

In reply to nevent1q…9050
_________________________

definitely viruses-- but help me understand why earth from space? aren't we seeing and photographing the earth? but for small unseen things we are inferring what is happening...

this is true. so much of what we think we "know" is based ...

2026-03-17T22:01:36+01:00

this is true.

so much of what we think we "know" is based on inference. it may be true or it may be a interpretation of results that we apply our imagination to in order to attempt to understand the results and explain those results to others.

we infer the existence of the double helix of DNA but is just a model that we create to understand the movement of electrical charges within a cellular structure.

quoting
nevent1q…fxux
Did you know that no human on Earth has never actually observed DNA??

The only “real” picture is a composite image…

It’s all CGI, just like space!!

a common theory is sanitation improves the health of the ...

2026-03-17T10:34:12+01:00

a common theory is sanitation improves the health of the population leading to the decline, but sanitation doesn't remove "viruses" (they are too small be filters by historic sanitation methods)

but if sanitation improves the health of the population so people don't produce the viral particles then it would make sense that cleanliness and toxins being removed from human consumption would decrease the "viral diseases"

quoting
nevent1q…xcdc
mortality trends for classic vaccines

Nostr event nevent1qqs8y9hg9ns5jj6prqg479mtyj6x0rg4tflvsa3j0dg5aqa74tw5xnszyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58utwtkw0

2026-03-17T08:35:38+01:00

In reply to nevent1q…xcdc
_________________________

https://mises.org/mises-wire/how-medical-licensing-serves-big-pharma-expense-public-health

mortality trends for classic vaccines ...

2026-03-17T07:47:04+01:00

mortality trends for classic vaccines

https://www.terrygodier.com/the-last-quiet-thing tools should be ...

2026-03-16T19:00:54+01:00

https://www.terrygodier.com/the-last-quiet-thing

tools should be predictable and only draw our attention when they are needed.

definitely a classic influencer post but for some people worth a ...

2026-03-16T14:00:28+01:00

definitely a classic influencer post but for some people worth a try. removing the social media apps is probabaly the biggest win for most people. no social media, no need for a phone.

thorne creatine is tested and i recommend but i believe lineage ...

2026-03-13T21:15:27+01:00

In reply to nevent1q…jpdf
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thorne creatine is tested and i recommend but i believe lineage is as well

creatine use for nicotine cessation: Only have anecdotal evidence ...

2026-03-13T20:25:39+01:00

creatine use for nicotine cessation:

Only have anecdotal evidence to support this in a handful of people who were all hooked on zyn pouches

Smokers had lower concentrations creatine in the medial prefrontal cortex compared to nonsmokers
https://pubmed.ncbi.nlm.nih.gov/33274546/

https://www.nature.com/articles/s41380-023-02247-0

creatine supplementation increases brain levels https://link.springer.com/article/10.1007/s40279-023-01870-9

nicotine lowers brain creatine → low brain creatine may impair prefrontal function and self-regulation → creatine supplementation might restore those levels and support cognitive function during withdrawal

two good review articles on the harms of food dyes 1. ...

2026-03-13T12:13:22+01:00

two good review articles on the harms of food dyes

1. https://pubmed.ncbi.nlm.nih.gov/23026007/

2. https://www.sciencedirect.com/science/article/abs/pii/S0924224425002213

Children are considered especially vulnerable due to their lower body weight (they get a greater weight based dose in a day)

Production of Red 40, Yellow 5, and Yellow 6 leaves behind contamination with benzidine and other carcinogens.

Dyes have been associated with a colitis, renal insufficiency, hepatotoxicity, pathological changes in the gut, and oxidative stress.

the joy you get from seeing your children try something new and ...

2026-03-10T03:24:01+01:00

the joy you get from seeing your children try something new and want to keep at it to get better supersedes all possible happiness your might get from work or material accolades

Nostr event nevent1qqs928anu44rs60sldc6kaf969vapgksy70q37puqcjm8lt3ffx2c2szyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58u492nnf

2026-03-09T18:23:26+01:00

https://reason.com/2026/03/05/the-tax-loophole-that-made-u-s-health-care-unaffordable/

the exclusion of employer-sponsored health insurance from taxable income has had unintended consequences (as most gov programs do)

Nostr event nevent1qqs23s8jahjprfvs94zr6ltsezy2wsfv0klw4tcfsf487t72q0xl56qzyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58usvn2wx

2026-03-07T18:06:50+01:00

absence of evidence ≠ evidence of absence

just started reading this. very good so far ...

2026-03-07T17:13:01+01:00

just started reading this. very good so far

at first i couldn't t believe this #nevent1q…0l2f

2026-03-06T11:27:18+01:00

at first i couldn't t believe this

quoting
nevent1q…0l2f
There unfortunately are no double blind randomized placebo controlled trials in clinical vaccine research. All of the trials use an "active" placebo for good reason. The adjuvent is probably the problem for humans not the innactivated dna/rna particle. Here is a list of placebos for vaccine trials:

1. HPV (Gardasil) Clinical Trial: Placebo was an aluminum adjuvant and the Hepatitis A vaccine.

2. Hepatitis A Clinical Trial: Placebo was the Hepatitis B vaccine.

3. Influenza A Clinical Trial: Placebo was the Influenza B vaccine.

4. Meningitis Vaccine Clinical Trial: Placebo was the DTaP (Diphtheria, Tetanus, and Pertussis) vaccine.

5. Pertussis Vaccine Clinical Trial: Placebo was the Diphtheria & Tetanus vaccine.

6. Prevnar-13 (Pneumonia) Clinical Trial: Placebo was the Prevnar-7 vaccine.

7. Hepatitis A Clinical Trial: Placebo was an aluminum adjuvant.

8. Prevnar-9 (Pneumonia) Clinical Trial: Placebo was the DTP-Hib vaccine.

9. Cholera Vaccine Clinical Trial: Placebo was the K-12 E.Coli vaccine.

10. Prevnar-23 (Pneumonia) Vaccine: Placebo was the Hepatitis A & B vaccines.

11. Polio Vaccine Clinical Trial: Placebo was a diluted polio vaccine.

12. Chicken Pox Vaccine Clinical Trial: Placebo was a diluted chicken pox vaccine.

13. Shingles Vaccine Clinical Trial: Placebo was a diluted shingles vaccine.

14. Some COVID-19 Vaccine Clinical Trials: Placebo was the Meningitis vaccine.

research institutions and professional schools are forced to use ...

2026-03-04T21:47:31+01:00

research institutions and professional schools are forced to use high priced research software with terrible UIs because the market is a niche without any competition

now with the cost of software approaching zero the people can make useful tools that respect privacy and costs.

introducing papertrace.org

https://papertrace.org/

Nostr event nevent1qqstdgsyw5ft33mz8mn83qe5z2wxwddgjn6j4jzuh7t2qej5kl9gduszyprr24dmfv8cplgnwmawv286h7hhuh33e5n5rkq25nfztjfxhs58u4mkhm9

2026-03-01T19:49:57+01:00

https://pubmed.ncbi.nlm.nih.gov/29067814/

imho consuming exogenous ketones is a bad idea ...

2026-02-28T23:41:20+01:00

imho consuming exogenous ketones is a bad idea

https://www.mdpi.com/2072-6643/18/4/675

co-sleeping ≠ randomly sleeping with your infant. co-sleeping ...

2026-02-27T14:44:55+01:00

In reply to nevent1q…k62t
_________________________

co-sleeping ≠ randomly sleeping with your infant. co-sleeping is a deliberate process of preparing the environment to be infant and mother first

yes! i'll set it up soon

2026-02-27T13:42:50+01:00

In reply to nevent1q…3sln
_________________________

yes! i'll set it up soon

co sleeping is not associated with sids ...

2026-02-27T13:36:48+01:00

co sleeping is not associated with sids

i'm pretty sure self sovereignty is going to win with these ...

2026-02-25T22:24:14+01:00

i'm pretty sure self sovereignty is going to win with these LLM coding tools.

i run one of the large healthcare wikis for emergency medicine (wikem.org) and many AI providers just scrape our data and providers are starting to ask chat boxes what to do on shift rather than reading a wiki page.

there is no use fighting them to take down queries with our data especially since it is creative commons.

so instead, by using their LLMs i built an LLM powered search for emergency docs

https://wikem.ai/

probably the glut-4 transporter causes this phenomenon ...

2026-02-24T13:41:01+01:00

In reply to nevent1q…ngpr
_________________________

probably the glut-4 transporter causes this phenomenon https://pmc.ncbi.nlm.nih.gov/articles/PMC8260367/

walking after a meal helps with glucose spikes as your muscles ...

2026-02-24T12:17:17+01:00

walking after a meal helps with glucose spikes as your muscles contract and use the glucose that is spiking post consumption

During sleep—particularly slow-wave (deep) sleep—your body ...

2026-02-24T02:51:06+01:00

During sleep—particularly slow-wave (deep) sleep—your body upregulates mitochondrial biogenesis, creating new, healthy mitochondria to replace aging ones.

https://pubmed.ncbi.nlm.nih.gov/29478834/

this is "the mandibles" except at least there was a push ...

2026-02-23T01:06:46+01:00

this is "the mandibles" except at least there was a push for multigenerational households out of necessity

quoting
nevent1q…6wwh
US elderly programs now at record 9.4% of GDP, up 56% since the late 1980s.

CBO projects 11.3% by 2036.

many nutritionists cite the Shanghai Women's Health Study ...

2026-02-18T23:58:41+01:00

many nutritionists cite the Shanghai Women's Health Study when defending soy as part of a healthy vegetable based diet

https://pmc.ncbi.nlm.nih.gov/articles/PMC2683002/

It was a prospective cohort studies on diet and chronic disease in Asian women. Launched in 1996-2000, it enrolled approximately 75,000 Chinese women aged 40-70 and has tracked them for decades through follow-up surveys and health record linkage.

It cites lower breast cancer risk with soy consumption and attempts to explain that Isoflavones (genistein and daidzein), which are phytoestrogens may modulate estrogen metabolism and have anti-proliferative effects on breast tissue....

but the study really demonstrates that fermented soy products (Miso, Fermented Tofu, Tempeh)
not soy supplements like soy protein may be good in a traditional eastern diet

Unfermented Soy (Tofu, Soy Milk, Soy Powders) are highly processed soy protein isolates or that lack the fermentation byproducts found in whole or fermented soy foods and deliver doses of isoflavones 2-3 times what you'd get from equivalent protein in tofu or tempeh

yeah... unfortunately

2026-02-17T21:18:53+01:00

In reply to nevent1q…h34s
_________________________

yeah... unfortunately

i use a glass/steel aeropress to get plastic free coffee but here ...

2026-02-17T18:57:05+01:00

i use a glass/steel aeropress to get plastic free coffee but here is a drip machine alternative

https://puresteelco.com/

mental health tip: silence as many notifications as possible. ...

2026-02-17T17:48:46+01:00

mental health tip: silence as many notifications as possible.

this will help make every interaction with communication tech purposeful and minimize anxiety from non urgent interruptions

creatine in older adults ...

2026-02-15T19:25:10+01:00

creatine in older adults
https://pubmed.ncbi.nlm.nih.gov/35984306/

I think far too little attention is being given to the effects of ...

2026-02-15T01:30:19+01:00

I think far too little attention is being given to the effects of abnormal and stressful growth conditions on the plants' natural defense systems. Plants normally synthesize some toxins and inhibitors of digestive enzymes to discourage attacks by bacteria, fungi, insects, and other predators. When a plant is injured or otherwise stressed, it produces more of the defensive substances, and very often they communicate their stress to other plants, and the resulting physiological changes can cause changes in seeds that affect the resistance of the progeny. (Agrawal, 2001)

One of many substances produced by plants in response to injury is chitinase, an enzyme that breaks down chitin, a polysaccharide that is a structural component of fungi and insects. Chitinase, which is produced by bacteria and humans, as well as by plants and other organisms, is involved in developmental processes as well as in the innate immune system. In plants, the enzyme is induced by ethylene and salicylate, in animals by estrogen, light damage, and infections, and can be demonstrated in polyps and cancers.

-https://raypeat.com/articles/articles/milk.shtml

ignore noise focus on first principles

2026-02-14T02:34:02+01:00

ignore noise

focus on first principles

💯 especially important for the elderly #nevent1q…44ny

2026-02-12T16:14:20+01:00

💯
especially important for the elderly

quoting
nevent1q…44ny
Not sure if this is a function of beng adhd my whole life but my brain state absolutely changed for the better when I started taking 10-20 grams of creatine everyday.

https://nourishfoodclub.com/

2026-02-10T23:23:18+01:00

https://nourishfoodclub.com/

wasn't aware of these guys. great site!

2026-02-10T23:22:41+01:00

In reply to nevent1q…xupw
_________________________

wasn't aware of these guys. great site!

from seed oil scout's egg testing: "The primary driver of ...

2026-02-10T22:40:46+01:00

from seed oil scout's egg testing:

"The primary driver of high Omega-6 (linoleic acid) in chicken eggs is the feed. Conventional chickens are raised on a slurry of corn and soy—both crops that are high in unstable polyunsaturated fatty acids (PUFAs).

-Conventional Feed: A ratio of nearly 11:1 (Omega-6 to Omega-3).

-Soy-Free Feed: A ratio of approximately 4.5:1.

The Sunflower Swap: Some farms (Shirttail Creek) remove soy but replace it with sunflower oil or meal, which is also high in linoleic acid.

The Flax Hack: Other farms pump chickens full of flaxseed to artificially jack up the Omega-3 numbers on the label. "

Since your eggs may have more linoleic acid than ideal it is best to keep all your other sources low and your total as low as possible.

in texas, Ken's Henz are a great non soy non-gmo choice

in medicine, there is a saying: "don't just do something, ...

2026-02-09T16:49:53+01:00

in medicine, there is a saying: "don't just do something, stand there"

often observing, waiting, being patient and staying calm is the best and hardest course of action

there may be a time to act, but that time does not always have to be now

don't fear fructose! as long as you are not consuming ...

2026-02-09T12:47:51+01:00

don't fear fructose!

as long as you are not consuming excessive calories compared to your energy demands, fructose does not produce harmful effects.

however, excess fructose above your caloric needs does get converted to bacterial endotoxins in the gut which damages multiple organs, specifically the liver

so the most important point in creating health, is balancing energy demands with the beneficial effects of carbohydrates

https://pubmed.ncbi.nlm.nih.gov/22457397/

the average highly paid professional is still clueless to the ...

2026-02-07T16:05:28+01:00

the average highly paid professional is still clueless to the superhuman power that LLMs give to a motivated employee.

need to create the skeleton of an research protocol: BAM!

need to review an unnecessary long document: BAM!

need to write R code to analyze a dataset: BAM!

need to generate a schedule for multiple shifts times while taking into account vacation requests: BAM!

this is only the beginning. one person with digital help can centralize 10+ jobs and have more time for dog walks

homemade glyphosate free flour, ghee from @nprofile…e667 , ...

2026-02-07T15:41:51+01:00

In reply to nevent1q…md5g
_________________________

homemade glyphosate free flour, ghee from GreatGhee (nprofile…e667) , organic honey...homemade cornbread with butter... all very different made with ingredients your great grandmother would recognize

3d printed? can y share the process and files?

2026-02-07T14:43:06+01:00

In reply to nevent1q…8npq
_________________________

3d printed? can y share the process and files?

my kids have never had a bowl of cereal. they have eaten cereal ...

2026-02-07T14:41:07+01:00

my kids have never had a bowl of cereal. they have eaten cereal even terrible ones but always dry and always in the setting of it being like "halloween candy".

even the concept of cereal for breakfast grosses them out since they are so used to homemade pancakes, muffins, eggs, bacon, sausage and filling food for breakfast.

if you start kids young with delicious foods and explain to them why we eat different breakfast from their friends they don't fight you and embrace good eating.

we tried saying "you can't have fruit loops" but it wasn't as effective as me letting them have fruit loops when on vacation and showing them that 2 hours later they were hungry and moody for them to understand our reasoning.

talking to kids like they are adults instead of just saying "no" is never as effective as helping the learn from experience, especially bad experiences.

High Protein Efficiency Ratio —> Supports Tissue Growth • ...

2026-02-05T12:36:04+01:00

High Protein Efficiency Ratio —> Supports Tissue Growth

• High Net Protein Utilization/ High Biologic Value —> Efficiently used by the body

• High Protein Digestibility Corrected Amino Acid Score —> Contains the needed amino acids

https://pubmed.ncbi.nlm.nih.gov/32835617/

i unplugged from all news several years ago. when at work i ...

2026-02-03T14:07:41+01:00

i unplugged from all news several years ago. when at work i always find out about the newest thing and getting information by word of mouth is a wonderful filter.

i spend a lot of time reading books, scientific papers and using computers and technology but have become allergic to news alerts, latest thing podcasts, and twitter like feeds.

mostly on nostr I post and ghost and prefer content that is first principled and scientific or has stood the test of 5+ years of time.

almost all of the academic busy work that faculty deal with such ...

2026-02-03T01:06:20+01:00

almost all of the academic busy work that faculty deal with such as grant writing, paper writing, yearly performance review and peer review is made 1000 times easier with large language models and moonshot. K2 is a game changer.

once you get on a glp-1 you will be on it for life unless you ...

2026-02-02T00:25:37+01:00

once you get on a glp-1 you will be on it for life unless you also make significant lifestyle modifications.

and when you get off it the weight will come back faster than the losses

https://www.bmj.com/content/392/bmj-2025-085304

when you play a greyscale game, your mind activates to fill in ...

2026-01-31T17:23:44+01:00

when you play a greyscale game, your mind activates to fill in the color. it is also easy to put it down because it i less "addictive" due to lower visual stimulation.

my kids love puzzle games on daylightco (nprofile…wsk5) and it is fun to watch them team up to solve them.

embrace boredom. sometimes it is exactly what your brain needs

2026-01-31T11:55:56+01:00

embrace boredom.

sometimes it is exactly what your brain needs

our need for sleep and the importance of long amounts of ...

2026-01-28T23:46:38+01:00

our need for sleep and the importance of long amounts of uninterrupted sleep may be driven by our mitochondria

During wakefulness, your neurons fire constantly, consuming enormous amounts of ATP. This drives the electron transport chain (ETC) at maximum capacity, which creates two critical problems: energy depletion and oxidation

1. Energy depletion: ATP gets hydrolyzed to ADP and AMP. The resulting low ATP/ADP ratio is a direct metabolic stress signal. Adenosine (formed from these breakdown products) accumulates and is a well-established sleep pressure molecule.

When we sleep neuronal activity decreases, allowing the electron transport chain to operate at lower capacity and reducing oxidation production and allow the reduction (opposite of oxidation) to catch up

the mitochondrial quality control mechanisms (mitophagy, biogenesis, fission/fusion dynamics) actively repair damage and replace dysfunctional mitochondria at a greater rate during sleep.

https://www.science.org/content/blog-post/it-all-comes-down-mitochondria

it is widely accepted in veterinary medicine that many canine ...

2026-01-27T14:30:53+01:00

it is widely accepted in veterinary medicine that many canine skin disorders are as a result of zinc deficiency and poor gut health. after treating any topic fungal or bacterial infections, most vets will suggest a probiotic supplemented with minerals to maintain high quality fur grown and skin health. very rarely do we see this offered in human medicine but it in fact clears up many skin issues though to be "autoimmune"

https://link.springer.com/article/10.1007/s40257-019-00484-0

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0625.2009.00932.x

the basis of modern virology ...

2026-01-27T14:11:32+01:00

the basis of modern virology

in medicine it is always enlightening to find natural controls. ...

2026-01-27T02:51:47+01:00

in medicine it is always enlightening to find natural controls. the Amish population serve as a human control --- but from a genetic standpoint, chimps serve as a control as well.

chimps in captivity have an approximate 2% cancer incidence yet share 99% similar genetics as humans. either that 1% genetic difference accounts for all of the increased malignancies in humans or humans have done something to themselves that create all of the malignancies that plague our modern health.

many will say that we get cancers because we live longer but captive chimpanzees live twice as long (15+ years more) than wild chimps so their lack of cancer is eye opening.

https://pmc.ncbi.nlm.nih.gov/articles/PMC1382208/

People feel invigorated after an ice bath because cold receptors ...

2026-01-25T14:12:11+01:00

People feel invigorated after an ice bath because cold receptors in your skin trigger sympathetic nervous system activation. Plasma norepinephrine and dopamine spike within seconds since your physiologic response is to "get out as fast as possible"

Then your pituitary gland pumps out beta-endorphins to bind opioid receptors to counteract the pain of the cold exposure (just like a runners high)

Vasoconstriction shunts blood to your core. When you exit, peripheral vasodilation creates a surge of oxygenated blood to your muscles and brain.

Your cognitive override of all these systems trying to get you out of the bath is fed by a later dopamine reward and your normal warm environment then feels like a luxury.