2026-07-22T23:48:49Z https://nostr.ae Mark Histed https://nostr.ae/npub1lxpejzd0l5dspe20tmx3atf36hx0uyu6cvepvvfnc7r9kpjs0xgs7z7dkh https://fediscience.org/system/accounts/avatars/109/306/813/114/013/393/original/1b92d4bd05476665.jpg https://fediscience.org/system/accounts/avatars/109/306/813/114/013/393/original/1b92d4bd05476665.jpg https://nostr.ae/nevent1qqsdfuqzytvg29p9pjrx8n3dqp6ep9lxk6t2vgwl2gmdxkufczvu6ygzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezfjzzut In reply to <a href='/nevent1qqs8zlltzuc0xmcv6t6q5ehtrqh6tuh7nk230svu79flfkpnql8aq7q7s63kr'>nevent1q…63kr</a><br/>_________________________<br/><br/>Hopefully this moves the needle and encourages the pharma industry to speak up.<br/><br/>I have heard from several sources that pharma execs know exactly what’s going on and what the damage will be, but they can justify inaction because the effects won’t hit their stock prices soon. 2026-05-31T13:23:37Z https://nostr.ae/nevent1qqs8zlltzuc0xmcv6t6q5ehtrqh6tuh7nk230svu79flfkpnql8aq7qzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezttwq90 In reply to <a href='/nevent1qqs080m89ls06nsfmxm8kxgm2juswuc9ratjkjy6ygfkyaefzrllncg9a3ps2'>nevent1q…3ps2</a><br/>_________________________<br/><br/>“The damage inflicted over the past 16 months is prologue.<br/>The OMB’s proposal for overhauling U.S. government grantmaking would explicitly subordinate expert peer review to political gatekeepers and make ideological alignment with the administration a prerequisite for funding.” 2026-05-31T13:23:32Z https://nostr.ae/nevent1qqs080m89ls06nsfmxm8kxgm2juswuc9ratjkjy6ygfkyaefzrllncgzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezuphfjy In reply to <a href='/nevent1qqsg4zpfa8tfm70d03tyd74kjzshmjrrc6tp7jf6a6cef39yly0j2qqnku4rz'>nevent1q…u4rz</a><br/>_________________________<br/><br/>“The argument, advanced privately by some industry leaders, that intervention would be futile is not credible. Technology executives recently persuaded the administration to abandon a proposed executive order on artificial intelligence…” 2026-05-31T13:23:24Z https://nostr.ae/nevent1qqsg4zpfa8tfm70d03tyd74kjzshmjrrc6tp7jf6a6cef39yly0j2qqzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puez38jluc In reply to <a href='/nevent1qqs0q5jhezhnl9l8348u8v9a9hfn88lr65gqy9zuxwslsf6prvc3t9qg733sc'>nevent1q…33sc</a><br/>_________________________<br/><br/>Biocentury is pharma trade press and widely read in the industry. 2026-05-31T13:23:13Z https://nostr.ae/nevent1qqs0q5jhezhnl9l8348u8v9a9hfn88lr65gqy9zuxwslsf6prvc3t9qzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezywknv7 “As the admin moves from cutting budgets and attacking elite universities to dismantling the foundations of the US research enterprise, pharma CEOs have remained silent.<br/>Their silence is a choice.” <br/><a href="https://www.biocentury.com/article/659615">https://www.biocentury.com/article/659615</a><br/> <img src="https://fediscience.org/system/media_attachments/files/116/669/400/996/215/638/original/6367eef1486ea749.jpeg"> <br/> 2026-05-31T13:23:03Z https://nostr.ae/nevent1qqs8v5fsjw2z3kvc4w6f98dhpwz7me0q45s9gytgsdhxvs3lqadg03szyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezsvkr22 In reply to <a href='/nevent1qqsgsdw55scnu5wtmekmhqzc5u7wvs9gw9qxdg8qzv7w0dj2gud398qs6hjx7'>nevent1q…hjx7</a><br/>_________________________<br/><br/>So we choose a reasonable rigor std, do our best to peer review, &amp; accept some errors, worked out by followup work. <br/><br/>(There are many issues w/ glam journals, over-selling, favoring huge labs—etc. But this &#39;some are wrong&#39; issue is just the nature of reality.) /end 2026-05-06T21:04:24Z https://nostr.ae/nevent1qqsgsdw55scnu5wtmekmhqzc5u7wvs9gw9qxdg8qzv7w0dj2gud398qzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezjlvvwn In reply to <a href='/nevent1qqs0m3xpjjmjth9wsrr4f3xpy3qacaxr8nnd7yldrkw76fxugq78qycxqphsg'>nevent1q…phsg</a><br/>_________________________<br/><br/>This framework is well-worked out in theory—we must choose an error criterion (&#34;wrong&#34;), which comes w/ a cost in time/$.<br/><br/>This isn&#39;t ex it (need a cost term), bt same idea, fm David Heeger&#39;s notes.<br/><br/>Type 1/2 errors, sensitivity/specificity: same idea.<br/><br/><a href="https://www.cns.nyu.edu/~david/handouts/sdt/sdt.html">https://www.cns.nyu.edu/~david/handouts/sdt/sdt.html</a><br/> <img src="https://fediscience.org/system/media_attachments/files/116/529/657/235/270/666/original/5c5c14adf5308acb.png"> <br/> 2026-05-06T21:04:19Z https://nostr.ae/nevent1qqs0m3xpjjmjth9wsrr4f3xpy3qacaxr8nnd7yldrkw76fxugq78qyczyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puez436sfp In reply to <a href='/nevent1qqsd4kp03suh7efuewhd3mlzrxh3le4n60xs33em7arj5hv76jsh0vqwk84rn'>nevent1q…84rn</a><br/>_________________________<br/><br/>Why not a bad thing?<br/><br/>Because these journals by def&#39;n are publishing exciting, novel, possibly field-changing work.<br/>You do NOT want to further encumber that work—CNS papers are far too long already—with a sky-high rigor standard. Or you will get rigor mortis of science.<br/>3/ 2026-05-06T21:04:13Z https://nostr.ae/nevent1qqsd4kp03suh7efuewhd3mlzrxh3le4n60xs33em7arj5hv76jsh0vqzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puez3jy5j5 In reply to <a href='/nevent1qqswhv7vjwurcfd4meaemazr3d9me5f26myukt4plyddetwwtz8ry2quly692'>nevent1q…y692</a><br/>_________________________<br/><br/>Every scientific mentor I know, including me, tells all our first-year grad students this.<br/><br/>It&#39;s widely known inside science.<br/>2/ 2026-05-06T21:04:08Z https://nostr.ae/nevent1qqswhv7vjwurcfd4meaemazr3d9me5f26myukt4plyddetwwtz8ry2qzyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puez6caye8 A good number of papers in Science and Nature are wrong...<br/>and that&#39;s not a bad thing.<br/><br/>(What&#39;s something everyone in your field knows but people outside the field don&#39;t?)<br/>1/ 2026-05-06T21:04:02Z https://nostr.ae/nevent1qqs0dtaxpynueutm9sg4ry8t37z9a4z0ysdeu8yvu2htgs0hxngdgeszyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezmj0ygt Learned this week that both of my siblings live in Sears kit houses. They were solidly built - still in very good shape. 2025-12-27T20:03:21Z https://nostr.ae/nevent1qqsqlz9vctzmhadpvwtn6egrxrsl6y0xk0s86pqt5uk9kjunpzp7cgczyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puezufjjvy Seen on DC Metro<br/><br/>🙄<br/> <img src="https://fediscience.org/system/media_attachments/files/115/554/559/143/732/895/original/6d35ec93c2a48890.jpeg"> <br/> 2025-11-15T16:04:03Z https://nostr.ae/nevent1qqs2f48h0da3w3lht02g5swsdpmjxm7t6yeg9m5fek4vst9ljxdhy8szyruc8xgf4l73kq89fa0v684dx82uelsnntpny933x0rcvkcx2puez5ta22a Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates.<br/>Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain&#39;s densely connected recurrent networks operate. 🧪 2025-05-15T21:02:14Z