2026-08-04T01:47:19+02:00 https://nostr.ae Thomas Lumley https://nostr.ae/npub1w7usytm28qv0eh5p9yzh92hx7wvrufhun66sd7j4mzzfntwsdfdqvl0dfu https://fediscience.org/system/accounts/avatars/110/643/119/992/160/998/original/a1d817dcfacd9813.jpg https://fediscience.org/system/accounts/avatars/110/643/119/992/160/998/original/a1d817dcfacd9813.jpg https://nostr.ae/nevent1qqsw30p3mp37706ja63jz47eaevf9h79fzk4fcvae62tj9tlr600m3czypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495jjgvkd Two new results on Staph aureus bacteremia treatment from the SNAP Bayesian adaptive platform trial.<br/><br/>SNAP is much larger than any previous trial in this condition, and is set up to examine multiple questions at once and to add in new questions as old ones are answered. One concern for funders is whether you will actually find anything this way, so SNAP is also important to platform trial methodology.<br/><br/>The reports here are comparing two standard choices of antibiotic to see if one of them is better. <br/><br/>For pencillin-susceptible S. aureus (which, yes, still a thing), OG penicillin is better than advanced anti-staph penicillins (lower risk of kidney injury and probably lower mortality)<br/><a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00761-0/fulltext?rss=yes">https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00761-0/fulltext?rss=yes</a><br/><br/>For methicillin-susceptible (but not penicillin-susceptible), cefazolin is better than the anti-staph penicillins (lower risk of kidney injury and probably lower mortality)<br/><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2506905">https://www.nejm.org/doi/full/10.1056/NEJMoa2506905</a> 2026-06-18T08:50:25+02:00 https://nostr.ae/nevent1qqsv5u6g2t9vyqj35vcwyzvxavquegsvn7u8r3nptws6qx2xg2lj97szypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495e6rrvs The R Project is awarded the biennial Rousseuw Prize in Statistics <br/><a href="https://www.rousseeuwprize.org/2026">https://www.rousseeuwprize.org/2026</a> 2026-06-17T08:08:30+02:00 https://nostr.ae/nevent1qqsqm866yzelulu3jp00553taxrpnjk6z9uh66fzxj6lywxpqra49eqzypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495x8ekw7 #bloomscrolling <br/>Winter magnolias<br/> <img src="https://fediscience.org/system/media_attachments/files/114/956/756/257/147/866/original/2a6571e01694090e.jpg"> <br/> <img src="https://fediscience.org/system/media_attachments/files/114/956/756/716/859/671/original/5ea7f1b040a5e57b.jpg"> <br/> 2025-08-02T04:17:25+02:00 https://nostr.ae/nevent1qqspctqwh7uzqdr2d3pxtw0sj97w5zk39mgwd8awx6yvxqzus7ydw8gzypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495msf8z0 In reply to <a href='/nevent1qqsy57u7fxq7y6d45qu0wjxxlmaq2x87qj0ap4zdh8t7kqxfpwq394sz4dvvn'>nevent1q…dvvn</a><br/>_________________________<br/><br/>KILL IT WITH FIRE!!<br/><br/>ahem<br/><br/>I suppose there are perfectly innocent Oxalis species in some places 2025-06-01T09:13:07+02:00 https://nostr.ae/nevent1qqs0wv6gzyg543e7d3vl6qm8juk7hl8le0grfxlhsw95ke8mdgg3hhgzypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p4955vxwvm In reply to <a href='/nevent1qqsqq7vfzg73pll98r68pvzmtz0lex3c2uj95ha88nwn0hu5g4kgnecfgrm99'>nevent1q…rm99</a><br/>_________________________<br/><br/>you can use withCallingHandlers() to get at the information. In the image, I run the code inside withCallingHandlers() and print a stack trace from the handler before continuing. This doesn&#39;t save *the actual stack* like error() does. One could, but that requires deep copying of everything if you&#39;re going to continue, since the contents of the stack will change.<br/> <img src="https://fediscience.org/system/media_attachments/files/113/880/473/849/869/779/original/3c6e7c243e11efa9.jpg"> <br/> 2025-01-24T01:25:04+01:00 https://nostr.ae/nevent1qqsx07t4xj26nz2dh3jtfwxf8yts72kc8a9gjgpkag3wq2ur44wrz8szypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495kc3qfz Become ungovernable<br/> <img src="https://fediscience.org/system/media_attachments/files/113/699/473/874/708/894/original/dea9f85bf19353ba.jpg"> <br/> 2024-12-23T02:12:23+01:00 https://nostr.ae/nevent1qqspsdhnyshp8kef4ps8lskxzm887r678weswq30ch452agc55gqdhczypmmjq30dgup3lx7sy5s2u42umees03xlj0t2ph62hvgfxdd6p495z44phk Collinearity in regression: a quartet of dataset illustrating that collinearity diagnostics don&#39;t actually get you anywhere in either predictive or causal model selection<br/><a href="https://notstatschat.rbind.io/2024/11/21/collinearity-again/">https://notstatschat.rbind.io/2024/11/21/collinearity-again/</a> 2024-11-20T22:41:08+01:00