Last Notes
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I can never get enough of Mitchell and Webb. Alot more Mitchell these days with "The Unbeliveable Truth" and "Would I Lie To You."
The show he was on last year called Ludwig was pretty awesome too. Highly recommend.
https://vidsrc.me/embed/tt27846061
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Fuck off did I just get that in 2 guesses, no way 🥳🥳🥳🙏🍻🇬🇧☕️🌞🥳🥳🥳
#nevent1q…umfn
WORD5 #595 2/6
⬛⬛⬛🟧⬛
🟪🟪🟪🟪🟪
https://otherstuff.ai/word5/
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https://blossom.smartflow.social/4c94f787ae703f268f3d17b7c6e682f5f01a8bcc64a62ef3a80eb1ccc9c4e812.jpg
#meme #memes #memestr #plebchain
Are we the baddies? WE HAVE SKULLS ON OUR CAPS!!!
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Great article/essay you've done btw. Made an impact on me!
Just not almost all of the custodial ones. Strike just got here a few weeks ago.
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Laut Amazon hats 900 Seiten.
Direkt gesaved und nachher als epub aufn kindle 3g mit keyboard ziehen und lesen.
Danke fürs teilen.
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Continuing on from the lyrium project
(see inserts)
@LyriumProject
IN THEORY: EXPANDED DEEP DIVE
DAY 31–70: Tissue Differentiation Phase
v2.2 | Theoretical Only | Purely Speculative Framework
****Not approved for human use****
Building directly on the provided excerpt, here is a fully elaborated, mechanistic breakdown of the proximal scaffold “nail cradle”, the overall phase coordination, spatiotemporal cues, the nail bud milestone (~Day 50), the vascular plexus checkpoint (Day 40–45), theoretical monitoring, and why this 40-day window is the highest-risk period in current mammalian digit models.
1.
Theoretical Lyrium Implementation: Proximal Scaffold “Nail Cradle”
Design Concept
A specialized proximal “nail cradle” zone integrated into the Lyrium Carriage v3.0 scaffold essentially a 3–5 mm wide, curved, semi-rigid lattice positioned exactly where the residual nail would sit in a Zone II thumb amputation.
Component
Material / Feature
Purpose
Base platform
Laminin-511 / laminin-332 rich hydrogel (mimics basement membrane of nail matrix)
Maintains K14+ stem cell quiescence-to-proliferation switch
Micro-niches
50–100 μm diameter laminin-coated pores with Wnt-3a / R-spondin slow-release nanoparticles
Recruits or sustains K14+/K15+/Lgr6+ nail stem cells
Mechanical cue layer
Tunable stiffness gradient (5–15 kPa) + aligned collagen fibers
Mimics natural nail bed tension; guides dorsal-ventral patterning
Signaling interface
BMP-2 / BMP-7 micro-beads + FGF-10 gradient
Creates regeneration-specific ligand environment (nail mesenchyme → blastema feedback)
Biological Rationale (Grounded in Regeneration Biology)
K14+ nail epithelial stem cells form the nail stem cell niche. In real mammalian digit-tip models (mouse, human pediatric cases), preservation or activation of this niche is obligatory for blastema formation and sustained regeneration. The nail mesenchyme (Lmx1b+, Sfrp2+, etc.) secretes BMP ligands that reprogram surrounding mesenchyme away from fibrosis and toward blastema identity. Laminin-rich ECM is the native substrate that anchors these stem cells and enables Wnt-dependent signaling loops.
Theoretical Risk Mitigation
Absent or malformed nail → loss of dorsal signaling center → stalled blastema or ventral-only growth.
Countermeasure:
Pre-seed cradle with autologous iPSC-derived K14+ progenitors + apoptosis trigger if no bud by Day 45.
Fallback: Soluble Wnt/BMP cocktail delivered via cradle if endogenous niche is damaged.
2.
Overall Phase Coordination (Days 31–70)
This is not sequential tissue-by-tissue growth it is orchestrated, interdependent morphogenesis.
Scaffold Role as “Spatiotemporal Conductor”
The Lyrium Carriage acts as a programmable 4D bioreactor:
Cue Type
Scaffold Feature
Effect on Tissues
Spatial
Gradient channels + zoned stiffness
Bone distal-high BMP-2; muscle aligned microgrooves; nerve parallel conduits
Temporal
pH/temperature/enzyme-responsive release kinetics
Day 31–40: proliferation-dominant; Day 45–60: differentiation-dominant
Biochemical
Multi-factor depots (BMP-2, MyoD mRNA, NGF, VEGF)
Precise ligand gradients mimicking axolotl blastema → redifferentiation
Mechanical
Dynamic tension via smart polymer struts
Mechanotransduction guides alignment and hypertrophy
Theoretical Visible Milestone — Nail Bud ~Day 50
First macroscopic indicator of successful ectodermal-mesodermal crosstalk.
Nail bud emergence confirms:
K14+ niche is active
Wnt/BMP feedback loop to underlying blastema is intact
Dorsal patterning signals are propagating
In real mouse digit-tip regeneration, nail bud reformation correlates strongly with successful bone and soft-tissue regrowth.
Critical Checkpoint ~Day 40–45: Vascular Plexus Invasion
The make-or-break moment.
Newly forming tissues (cartilage anlagen, muscle bundles, nerve fronts) become metabolically demanding.
Without rapid ingrowth of a host-derived vascular plexus: necrosis of the entire construct.
Theoretical intervention window: VEGF + PDGF-BB pulse release + optional microsurgical pedicle enhancement.
3.
Theoretical Monitoring Protocol (Non-Invasive)
Frequency
Modality
What It Detects
Weekly
High-resolution OCT (1300 nm handheld)
Nail bud emergence, tissue layer boundaries, scaffold degradation rate
Bi-weekly
Contrast-enhanced ultrasound
Vascular plexus density & perfusion (critical Day 40–45)
Weekly blood / exudate
Biomarker panel
BMP-2 (bone patterning), NGF (nerve), MyoD targets (myogenesis), inflammatory cytokines
Day 50 milestone
Clinical photo + OCT
Nail bud confirmation → green-light full differentiation
4.
Why This 40-Day Window Is the Highest-Risk Period
Current limb/digit regeneration models (mouse, axolotl tissue-engineered constructs) show that mismatched timing between lineages is the #1 failure mode:
Bone ossifies too early → compresses nerve/muscle channels
Nerve lags → muscle atrophies
Nail signaling fails → mesenchymal dedifferentiation reverts to fibrosis
The Lyrium scaffold’s spatiotemporal programming is explicitly engineered to minimize these mismatches by enforcing coordinated gradients and mechanical cues.
#InTheory
lyrium.org/theory-phase-31-70
@LyriumProject - ( not currently running )
CC-BY-4.0 | Purely speculative — grounded in published regeneration biology
https://npub1j42rxzt0eg3r72ddl4f2psk7q73u2t4ksrumfk0td3rdjxtv2s8qk2u4jf.blossom.band/aecb13685a6ee480ea597fe69ff35f24925593920e240d626cb5aff7af9ed901.gif
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Did it for 100 sats.
Everyone gets to listen.
https://a.nostr.build/P00NAsgPXJ3u9rOd.wav
to the voice of Earl Nightingale.
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@npub123s…wk9x
https://a.nostr.build/P00NAsgPXJ3u9rOd.wav
Enjoy and thanks for the sats!
Of course there's nuance, but in a place where government is dysfunctional, service, by definition, are not provided. So decentralization takes place naturally, with people sorting themselves and their immediate community out. There is no expectation that government will provide anything.
OK!!! Complete :) Just uploading now.
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krompir. wait, how is it in bulgarian again. kartof. yess. kompyutar e kartof
🤖 Tracking strings detected and removed!
🔗 Clean URL(s):
https://www.bbc.com/news/articles/c1e2vxn67vjo
https://www.bbc.com/news/articles/c1e2vxn67vjo
❌ Removed parts:
?utm_source=flipboard&utm_medium=activitypub
?utm_source=flipboard&utm_medium=activitypub
Should we call you Jesse Pinkman? https://image.nostr.build/aef83fee86fc4ce7794f981df8f11dda75d4b6a8552496bd2b8bbd5cf929325f.jpg
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https://blossom.primal.net/6f23ec88632aa1adf52c21062bf67eb641cdd5292c1d09fb888ee18594087450.jpg
The progress is being made, few more days to go 🫡
#nevent1q…4q5z
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Lifehack: Sollte jeder so machen, dann wird es bestimmt keine zweite Auflage geben.
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Dollar et Euro : 85% de perte de pouvoir d’achat depuis 2007 – L’or, seul refuge pour protéger votre capital ! #or #euro #dollar
https://www.businessbourse.com/2026/05/22/dollar-et-euro-85-de-perte-de-pouvoir-dachat-depuis-2007-lor-seul-refuge-pour-proteger-votre-capital/
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