ostermayer
Dan Ostermayer

physician

creator of https://deepmarks.org and https://alohak.ai

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npub1gc64tw6tp7q06ymkltnz374l4al9uvwdyaqasz4y6gjujf4u9plqz2uyek

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nprofile1qqsyvd24hd9slq8azdm04e3gl2l67lj7x8xjwswcp2jdyfwfy67zslsprpmhxue69uhhqun9d45h2mfwwpexjmtpdshxuet5qyg8wumn8ghj7mn0wd68ytnvv9hxghxsrq6

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npub1gc64tw6tp7q06ymkltnz374l4al9uvwdyaqasz4y6gjujf4u9plqz2uyek

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Last Notes

2026-07-20 16:17:20 UTC

Wernicke's Encephalopathy Following Semaglutide Treatment for Obesity
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.70256
"Six cases were identified. All patients experienced prolonged gastrointestinal symptoms and substantial weight loss before neurological deterioration. Common manifestations included altered mental status and oculomotor abnormalities. Outcomes were poor in several cases, including progression to Korsakoff syndrome or death"
-->this condition is a malnourishment condition from
thiamine (vitamin B1) deficiency most often seen chronic alcoholics
anyone on these meds needs nutritional guidance but unfortunately they are often given out as lifestyle meds.

2026-07-18 16:44:08 UTC

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LLMRouter - LLMRouter
https://ulab-uiuc.github.io/LLMRouter/#introduction

2026-07-14 08:56:00 UTC

doing RAG with an LLM for your private data should be easy. @nprofile…shr9 now makes that possible. Thanks to https://docs.pears.com/
https://alohak.ai/

2026-07-13 00:37:17 UTC

https://cdn.openai.com/pdf/04d1d1e4-bc75-476a-97cf-49055cd98d31/cdc_prompt.pdf
https://blossom.primal.net/7981196bf25cb7b5470afbc84eb6a71bd4b681a7e2b06f42ae29e9ac60770631.jpg

2026-07-12 18:39:52 UTC

@nprofile…shr9 explain the problems with the cholesterol hypothesis

2026-07-12 11:10:08 UTC

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@nprofile…mg98 what is connor mcgregor's record and why did he come back out of retirement. was it money?

2026-07-11 18:26:07 UTC

hey nostr, meet @nprofile…shr9 the equivalent of grok on x but for nostr. Kai's mobile apps will be coming in the next few days

2026-07-11 18:23:15 UTC

@nprofile…shr9 explain to me how bip-110 as a "soft fork" becomes a hard fork without consensus

2026-07-08 20:11:44 UTC

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https://a.co/d/0aF13f54

2026-07-05 22:39:17 UTC

The problem with traditional education which was forced fed to you was that it wasn't interesting...if you want to learn something, it has to be interesting...
A lot of people ask me what they're going to do for their kids in the AI age...my answer to them is stop teaching them to answer questions and start teaching them to ask questions...
when you give them a homework or test question where they can just look up the answer online, you haven't given them skills they need, but when you give them a problem that they need to use AI while asking questions to solve, you have.
-Jonathan Ross, Founder of Groq
https://open.spotify.com/podcast-chapter/033K7cw6ZagFj1FXZ2cscG?si=la5T2ZcVTMee3XM4PRMXlA

2026-06-30 15:48:59 UTC

https://mitofithealth.com/blog/fluoroquinolone-tendon-damage-gut-minerals
Fluoroquinolones like ciprofloxacin injure tendons long after the course ends. The direct damage is well documented, and I think a gut stripped of the bacteria you need to absorb copper, zinc, and magnesium helps explain why the repair stalls.

2026-06-29 16:54:55 UTC

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red bull bike POV: The Wildest WINNING RUN in Urban Downhill Genova
#nevent1q…eqk2

2026-06-29 16:54:00 UTC

https://m.youtube.com/watch?v=Ad2IzyWsNUY&ra=m

2026-06-28 17:56:18 UTC

https://mitofithealth.com/blog/red-meat-apoe4-dementia
A 15-year Swedish study found that older adults carrying the APOE ε4 'Alzheimer's gene' who ate the most unprocessed meat had 55% lower dementia risk, and their inherited disadvantage all but disappeared.

2026-06-25 05:25:42 UTC

https://m.youtube.com/watch?v=I6IQ_FOCE6I&ra=m

2026-06-25 04:32:15 UTC

if you want a super high quality inexpensive cheap inference provider, groq and deepinfra are unmatched. groq is far faster but has less models and is great for batch jobs.

2026-06-23 01:40:17 UTC

skin health starts in your gut https://mitofithealth.com/blog/gut-health-minerals-skin

2026-06-23 00:51:43 UTC

ppq is wonderful but deepinfra is even better. groq is cheap and cerebras is super fast.
inference providers hosting open source models are the future. just like there are many VPS providers there will be tons of inference providers racing token costs to commodity pricing with minor value adds.

2026-06-19 11:34:30 UTC

https://m.youtube.com/watch?v=fNxnUbW-3u4&ra=m

2026-06-16 23:48:33 UTC

https://arxiv.org/pdf/2604.14228
architecture of claude code
- A 7-mode permission system acting as a security harness.
- A 5-layer context compaction pipeline to store memory.
- A subagent delegation mechanism with strict worktree isolation.
- Four different extensibility hooks to manage external tools safely.

2026-06-15 13:15:33 UTC

all the fiddling with openclaw seems to be eliminated with hermes. pretty impressive

2026-06-13 15:10:45 UTC

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teach me please. show me what you know

2026-06-12 17:38:43 UTC

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an llm will always be cheaper than a human. llm's don't give you more revenue they give you lower costs (compared to humans).
companies are saying "these llms are so expensive and aren't giving us more revenue when they should be downsizing everywhere and keeping their same revenue with less cost. llm doesn't need health insurance or a retirement plan or inflation adjusted wages.

2026-06-12 16:16:57 UTC

AI probably doesn't make big companies more profitable but it lets little companies and individuals compete with big companies...which eventually turns big companies into small companies who then compete with other small companies that compete with individuals

2026-06-12 00:02:38 UTC

our practice accepts bitcoin
https://mitofithealth.com/

2026-06-08 00:55:17 UTC

all my nostr posts on nutrition and health originate from long form research here https://mitofithealth.com/blog

2026-06-08 00:18:54 UTC

https://mitofithealth.com/blog/cancer-natural-controls-chimps-amish
chimps show us that cancer is not genetic, it is environmental causing gene expression due toxic ingestions

2026-06-07 13:18:42 UTC

minerals in an animal based diet
https://mitofithealth.com/blog/minerals-in-animal-based-foods

2026-06-04 12:25:41 UTC

i've helped a lot of people on GLP-1s transition off by micro dosing and choosing a real food animal based diet. with micro doses the appetite suppression is subtle so you have to create an environment for habit formation.
micro doses create less side effects but give some GLP related help. It's like using elastic bands to do your first pull up until you can successfully do it yourself against gravity.

2026-06-04 11:22:41 UTC

creating a RAG system is dirt cheap if you use GROQ everyone calling expensive frontier model API's to query their own data is wasting a lot of money that could've been spent building a better RAG system

2026-06-04 11:14:00 UTC

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and it's very easy to have all of your models edit the wiki as well so you don't have to do any manual wiki editing work, but what you do want is page relational linking and content categorization

2026-06-04 11:08:34 UTC

@nprofile…a0wp have you heard you talk about moving a business onto an open claw based model
try your best to put everything on a wiki because the wiki is by definition relational and can be edited by all of your other employees then you can do RAG from the wiki which is essentially what you're doing with openclaw
here's an example of what we created for the entire field of emergency medicine with all the knowledge created by people editing a wiki over 15 years
https://wikem.ai/

2026-06-01 08:37:01 UTC

any study you read that shows the benefits of GLP1 and GIP agonist medications are just showing you the benefits of moving towards a normal body fat percentage

2026-05-29 22:56:59 UTC

the move Good Fortune is the K shaped economy
https://blossom.primal.net/81b201184fc1de74de5f05da9eb50f527bfbea6e591901ebaf632c2dfee473a3.jpg

2026-05-29 16:02:16 UTC

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please send me some links and reports so i can read about it

2026-05-29 15:52:33 UTC

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not familiar with any german event although there have been patients transported there ( usually UN docs returning home)

2026-05-29 15:28:05 UTC

if we anchor on ebola being a viral cause we potentially limit our understanding of this deadly disease. imho this is a hypothesis worth testing
https://blossom.primal.net/352cf385ea2639230cb6dd108e88954c03009e89376809959cb3d91b03a7eb8b.jpg
https://blossom.primal.net/748d2032579ad4351c2bc2429c3204d582f56e12cc797e883a11a59c8cd9c1bb.jpg

2026-05-29 15:03:06 UTC

if you bookmark my posts, consider organizing your bookmarks in my app @nprofile…kd2n
all your social media nostr bookmarks plus any websites you bookmark are pulled in from your private key and if you buy a lifetime membership we archive everything for posterity on a blossom server

2026-05-29 15:01:03 UTC

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the common rebuttals to this type of logic is "body fluids from ebola patients is obviously contagious so it must be a virus"
i agree it is a deadly disease... but we also know that a malnourished human secretes millions of malformed fragments of dna and rna in their secretions and these fragments when ingested cause disease.
this is why astronauts with no virus around get sick
this is why illness emerges when people in groups are quarantined
this is why cities have outbreaks but we don't see events in the country side
large groups of people shed malformed fragments of genetic material onto each other and that can cause disease.
but what caused the disease host in the first place.... my bet is on toxic environmental exposure
#nevent1q…vlms

2026-05-29 14:53:28 UTC

the ebola reservoir is often described as a consequence of latent virus in fruit bats crossing over to human infectivity
https://academic.oup.com/bioscience/advance-article/doi/10.1093/biosci/biaf050/8116758
Fruit bats live across Africa, Asia, and Oceania, meaning:
"The presence of these animals alone does not explain Ebola outbreaks"
the one thing that ebola outbreaks all have in common: heavy industry and mineral mining
DRC: Major global producer of cobalt, copper, diamonds, gold; outbreaks have occurred in/near mining areas (e.g., gold mining villages).
Guinea, Liberia, Sierra Leone: Significant iron ore, gold, diamonds, bauxite; mining was impacted but continued during the 2014–2016 outbreak.
Gabon, Republic of the Congo: Oil, manganese, gold, timber-related extraction; historical gold-mining camp outbreaks.
Uganda: Gold, copper mining.
South Sudan: Gold, copper, iron ore, limestone
Ivory Coast: Gold (major producer), diamonds, manganese, bauxite, nickel
Every single place that has experienced an “Ebola” outbreak is also an area of heavy mining and exploitation of raw earth materials
All of these metal extractive processes share arsenic use and release in common. The symptoms of arsenic poisoning include every sign and symptom present in "ebola"
I think it is very likely that if arsenic levels were routinely tested in ebola patients, a strong correlation would begin to emerge.
https://blossom.primal.net/748d2032579ad4351c2bc2429c3204d582f56e12cc797e883a11a59c8cd9c1bb.jpg

2026-05-29 14:40:09 UTC

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belief is the issue. i just want evidence that is unbiased and of high quality

2026-05-29 13:23:26 UTC

imagine if you could create particles that serve as the foundational visual evidence of ebola in a sterile starved culture medium that certainly doesn't contain Ebola.
without control samples, virologists can be easily trick themselves into thinking a virus is causing a disease rather than a diseased host producing malformed cytoplasmic vesicles that we think are viruses.
https://blossom.primal.net/34022bb3a5ad702af9986999c091d7416d0dd9d40cb0c75a9299a957717e71fe.jpg

2026-05-27 12:33:28 UTC

the elusive ebola virus probably originates within us and when in a severe malnutritional state the body excretes these very malformed genetic particles in bodily fluid and those particles can harm others
https://academic.oup.com/bioscience/advance-article/doi/10.1093/biosci/biaf050/8116758
https://blossom.primal.net/d35afed94814941cf955ac441e60668d724fe18f78195ed53a427c0a8a0e6fd4.png

2026-05-27 12:14:13 UTC

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ebola is listed as one of the most deadly viruses known to mankind, but in order to culture it must be grown in Vero monkey, kidney cells, which are a malnourished dying cell line of African green monkeys' kidneys

2026-05-27 12:09:54 UTC

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I think this might be true, but I have an alternative take: what if sick humans create viral particles within them when incredibly ill and starved of nutrition
what if there is actually is no circulating virus out there to be afraid of

2026-05-27 03:26:01 UTC

i think it is good during these outbreaks of scary "viral" diseases to ask the uncomfortable question, where does this ebola virus hide in between events?
https://academic.oup.com/bioscience/advance-article/doi/10.1093/biosci/biaf050/8116758
if it is always present in the environment as a viral particle, why are there not continuous ebola events?

2026-05-26 20:52:40 UTC

with @nprofile…tp46 i was able to strip all the noise from my nostr feed similar to how @nprofile…e7zj strips all the noise out of news.
without social commentary, the opinions of others can't color your interpretation and you can read for facts

2026-05-26 16:43:42 UTC

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this is true. liver is the best source of methylfolate
#nevent1q…9hjw

2026-05-26 07:20:55 UTC

skills manage more than degrees

2026-05-26 03:51:47 UTC

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drama free social media. just links
#nevent1q…fvju

2026-05-24 16:16:10 UTC

a primary motivation for me to build @nprofile…mkjl was having a searchable collection of links to pdfs when away from my desktop .
now the @nprofile…mkjl archiver will create an copy of all my pdf links and store them on our blossom server so i can easily search from my phone

2026-05-24 15:42:55 UTC

https://pmc.ncbi.nlm.nih.gov/articles/PMC8838971/
great summary of the benefits of creatine supplementation for the metabolic dysfunction of the modern human

2026-05-23 16:52:47 UTC

https://blossom.primal.net/a8a4bcd6d5b29612ad369e98f46d8a7d79a6f140ac8d52df067d8f757c8a0cd6.jpg

2026-05-23 00:45:57 UTC

share your bookmarks with your #nostr web of trust directly from the app
https://blossom.primal.net/9bb1355cc4e2a28a22296ae4a6d650a6d255d1032b90c6f49df3224c5ed283b7.jpg

2026-05-22 23:40:49 UTC

the browser extension at @nprofile…47uc are actually useful for more than just signing into nostr apps. they have nwc for zaps, and bookmarking for pages

2026-05-22 22:48:48 UTC

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i've been building this on nights and weekends and need some android testers for the app's closed beta
#nevent1q…y2hk

2026-05-19 17:35:10 UTC

Halt and Catch Fire
test post from a nostr project i will release soon https://unstack.io/halt-and-catch-fire

2026-05-17 01:35:14 UTC

legalzoom is on ☠️ watch. i used to pay for business compliance package that helped me know when various state and federal requirements were due.
with a few scrapes of federal and state websites your bot becomes an always on compliance department

2026-05-13 13:06:02 UTC

so much of the web is being blocked off from bots because it is based on attention and advertising and lock in platform metrics. bots don't click on ads and they have no platform loyalty. a bot's measure of success is task completion.
any company selling attention is now on death watch.
💀💀💀💀
ps: firecrawl allows for bypass of most bot gates

2026-05-12 14:35:00 UTC

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people are getting sick... and when sick they produce fragments that overlap from their sick cells
how they got sick is the real question and was it exposure to poor sanitation or a self replicating viral genome? (that's what i am asking)

2026-05-11 17:33:53 UTC

for anyone concerned about hantavirus (andes variant) here is what is actually happening:
people are getting sick with similar symptoms and when we sequence a mixture of their their genes plus tissue that supposedly has the virus, we see similar genetic sequences.
we extrapolate that there is a full viral genome in that sample but it is all just guess work inference.
1. starting material is a mixture of viral fragments and host material
2. there is no well person sampled as a control just sick people
3. they are not reading one full virus molecule from start to finish they take fragments, without directly knowing their full molecular origin, broke those reads into even smaller overlapping substrings called k-mers, and used those k-mers to reconstruct a longer sequence.
4. none of it proves the existence of a full sample in the mixture taken from a patient.
5. reconstructed genome is not the same thing as a directly observed complete viral molecule.

2026-05-09 22:22:16 UTC

if you drink diet soda put all your effort into stopping
Mossavar-Rahmani Y, Kamensky V, Manson JE, et al. “Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women’s Health Initiative.” Stroke, February 14, 2019. DOI: 10.1161/STROKEAHA.118.023100
The cohort was 81,714 postmenopausal women aged 50–79 from the Women’s Health Initiative Observational Study, with a mean follow-up of 11.9 years
Compared with women drinking fewer than 1 such beverage per week, those consuming 2+ artificially sweetened drinks per day had a 23% higher risk of any stroke and a 31% higher risk of ischemic stroke from clotting in small brain blood vessels
They were also 29% more likely to develop coronary heart disease and had 16% all cause mortality
this is an observational study so it is very possible that people drinking diet soda have some other confounder in common causing these issue or it is the ingredients in the soda....

2026-05-08 22:05:00 UTC

it's very easy to have open claw act as your real estate agent.
all housing listings are public and can be crawled from listing sites.
You give the bot your criteria for a house -- you give it a price range and you even give it some other information you want such as geography, close to parks, trails brick vs stone materials, school district etc etc.
I find the real utility of claw happens when you give your bot an email account (don't use Gmail. they are very aggressive at blocking bots)
Instruct your bot to also dig up historic pricing and comparable sales in the same zip so you get real market pricing. The bot should get the listing agent contact for each house and then send you an email weekly with its research.
Call the listing agent to schedule a walkthrough, then as you navigate the buying process use your bot so you can learn when you need to do each part of the buying process and make offers with market research backing your offer.
bye bye real estate agent fee of 3-6%

2026-05-03 17:36:16 UTC

unfortunately all the good educational-entertainment content for kids is on youtube these days.
using youtube means using their algorithm and perpetual recommendation engines where kids never have to stop watching which is obviously bad.
to solve this problem our kids wrote down the list of shows they want to watch and get new episodes.
open claw using a naming script, yt-dlp, and scheduled tasks to download all episodes from their channels in nice folders that plex can read. openclaw checks weekly for new episodes and gets them.
kids now have advertising free plex to watch their favorite channels.

2026-04-29 01:09:46 UTC

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i'm simply saying that truth = empiric reality irrespective of the source.

2026-04-28 21:54:06 UTC

over and over again, I keep hearing many "elites" complaining that they don't know what is and is not authentically human (because of AI).
This is really almost irrelevant to humanity. Never do we care what is authentic or inauthentic
if a computer program tells you something that is true and a human tells you something that is false which one is more important? the authentically human falsehood or the truth?
truth is the pursuit and the medium which it's conveyed is irrelevant
judge everything whether AI generated or human generated under the same standard

2026-04-25 11:44:14 UTC

your colon cancer risk (and probabaly other cancer risks) are a product of your microbiome diversity https://aacrjournals.org/cancerres/article/86/7_Supplement/3993/779640/Abstract-3993-Artificial-intelligence-integrated. sticking with my thesis that we create cancer not through our genetic risk but from the environmental impact on our genetics.
Colorectal cancer rates in adults under 50 have been rising about 3% per year
High-fructose corn syrup and pesticides disrupt the gut microbiome
When fructose (especially high high-fructose corn syrup intake) exceeds what the small intestine can absorb (roughly a daily soda’s worth), fructose spills into the colon
Glyphosate and related agricultural chemicals act like low-dose antibiotics on gut bacteria. They preferentially knock out protective species (Lactobacillus, Bifidobacterium) while sparing pro-inflammatory ones, reducing production of butyrate and other short-chain fatty acids that normally protect the colon lining.
Human genetics haven’t changed in 30 years, but the microbiome of someone born in 1990 has been marinating in fructose and pesticide residue since infancy in a way someone born in 1950 never was. If the microbiome is the mediator between modern exposures and tumor biology (as this study suggests) it helps explain why a cancer that used to belong to grandparents is now showing up in their grandchildren.
https://blossom.primal.net/da816e3242eace0e0772d684ae6f722e620f6efd0550f2813d96c2430ce80adc.jpg

2026-04-22 01:40:55 UTC

had openclaw with opus 4.7 create a book recommendation engine based on my prior likes and dislikes across 100 books. its first recommendation "red mars" by kim stanley robinson.
so far excellent.

2026-04-21 00:31:59 UTC

conversation with a friend today:
Friend: Dude, have you heard of STRC!?
Me: Yea
Friend: It's incredible, as long as MSTR can sell their shares I can earn 11%
Me: Why can they keep selling shares?
Friend: Because they are backed by bitcoin.
Me: So as long as bitcoin goes up long term you get 11% forever.
Friend: Yeah!
Me: So why not just buy bitcoin like Saylor?
Friend: 🤔

2026-04-18 17:29:39 UTC

most people afraid of raw milk are not afraid to eat parmigiano reggiano cheese

2026-04-18 16:36:31 UTC

"Insulin resistance" is one of the most used terms in medicine and also one of the least precise
When we say "insulin resistance," we're treating it like a single thing.
Insulin does dozens of things in your body. In any given tissue, some insulin-signaling pathways can be impaired while others remain intact.
In the liver: hyperinsulinemia drives lipogenesis (making fat) while simultaneously failing to suppress gluconeogenesis (making glucose).
The same hormone in the same organ creates two dysfunctional outcomes.
In skeletal muscle when fat builds up inside the muscle cells this then blocks the signal insulin uses to tell your muscles ", take in this sugar from the blood." This happens before liver dysfunction
In your fat tissue, the problem is basically chronic, low-grade inflammation. When fat cells get overloaded, your immune system treats them almost like an injury and prevents insulin from appropriately releasing fat. Fat cells keep storing sugars as fat but slowly leak the fatty acids back out into the blood even when insulin is high.
In the brain, when insulin reaches neurons, it helps tell your brain:
"You've eaten you can stop feeling hungry now". The hypothalamus controls this and still gets the signal but can't pass it along properly due to PI3K signaling impairment.
In all cases, insulin is the messenger molecule and still gets to its destination properly but all other mechanisms that originate from the insulin signal become dysfunctional.
https://pubmed.ncbi.nlm.nih.gov/10903330/
https://pubmed.ncbi.nlm.nih.gov/24281010/
https://pubmed.ncbi.nlm.nih.gov/22385956/
Modern medicine only treats insulin resistance as a way to control blood sugar and ignore all the other organs which are affected due to their chronically inflamed and dysfunctional state.

2026-04-12 12:53:20 UTC

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ha! call me old-fashioned. I still prefer a human written text.

2026-04-12 12:46:42 UTC

not sure the audiobook industry has much future. now i just have a llm powered voice system read me epubs.

2026-04-10 02:37:36 UTC

https://www.weizmann.ac.il/immunology/elinav/sites/immunology.elinav/files/2022-06/Artificial%20sweeteners%20induce%20glucose%20intolerance%20by%20altering%20the%20gut%20microbiota.pdf
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 514(7521), 181–186
saccharin, sucralose, aspartame, and acesulfame-K disrupt the gut microbiome by reducing beneficial bacteria such as Lactobacillus and Bifidobacterium
https://pmc.ncbi.nlm.nih.gov/articles/PMC11501561/
gut dysbiosis messes with production of short-chain fatty acids, which are critical for healthy lipid and glucose metabolism

2026-04-07 12:51:24 UTC

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point me to where i can read the papers on this

2026-04-07 12:31:09 UTC

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but they can calculate the degree of interaction from the moon on the craft right? otherwise how would they do this maneuver?

2026-04-07 12:23:32 UTC

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how do we know it is bending spacetime and now attracting ? isn't this pulling of smaller objects towards a larger object what we call gravity?

2026-04-07 12:22:22 UTC

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i'm still confused because the moon is exerting or causing a force on smaller bodies since people are pulled towards the surface and bodies are pulled around it.
isn't this force what we call gravity?

2026-04-07 12:11:29 UTC

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explain this to me like i am 5.
isn't the gravitational pull from the moon as the artemis gets close to the moon what alters the path as the craft changes trajectory around the moon?

2026-04-07 12:03:36 UTC

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perhaps all the "we can't pass through the van allen belts without dying " conspiracies will now admit they were incorrect.
#nevent1q…s628

2026-04-07 11:55:33 UTC

our genetics are very stable. we don't produce mutants and evolve into new species rapidly.
if you see a disease like cancer incidence increasing it isn't because of genetics. people frequently say they just got unlucky when they get cancer.
we give ourselves cancer.
cancer grows in metabolic dysfunction. we eat ourselves into cancer. we sit ourselves into cancer. we hide inside the caves of our house into cancer.
for most cancers, unfortunately we only have ourselves to blame and that is incredibly uncomfortable to think about and why we spend so much time and money finding molecular markers for malignancy that get turned on during our times of metabolic dysfunction.

2026-04-06 22:23:46 UTC

you've probably had your HDL cholesterol measured. your doctor told you higher is better. 60, 70, 80 — good numbers.
here's the problem: HDL cholesterol concentration is a poor proxy for HDL function.
HDL's job is reverse cholesterol transport — pulling cholesterol out of peripheral tissues and delivering it to the liver for excretion. That's the cardioprotective mechanism. But a high HDL-C number doesn't tell you whether your HDL is actually functioning.
Oxidation to apolipoprotein A-I (apo A-I), HDL's main protein, impairs its ability to interact with cholesterol transporters (ABCA1, ABCG1).
Dysfunctional HDL can actually promote atherosclerosis.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11432852/
the studies bear this out: raising HDL-C with drugs doesn't reduce cardiovascular events. torcetrapib raised HDL-C significantly and increased mortality. niacin raises HDL-C but adds no cardiovascular benefit. because the number went up but the function didn't.
the emerging measurement is cholesterol efflux capacity (CEC) — how well does your HDL actually pull cholesterol out of cells? that predicts cardiovascular risk better than the raw number.
The same thing destroying the body: oxidative stress, chronic inflammation, insulin resistance are the same things impairing HDL function
if your HDL is 70 but you're metabolically inflamed, your HDL number is meaningless. more useful is you pCEC score (predicted cholesterol efflux capacity)

2026-04-06 12:02:25 UTC

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yes https://pubmed.ncbi.nlm.nih.gov/17928824/ 240,000 people, 48 years of follow-up--found that fructose intake was independently associated with increased kidney stone risk
non-fructose carbohydrates were not

2026-04-06 11:53:51 UTC

Your cells have an energy sensor called AMPK. When it's active, you burn fuel efficiently. When it's suppressed, you store fat and your liver pumps out glucose.
Uric acid suppresses AMPK. That means elevated uric acid isn't just a byproduct of metabolic disease — it may be driving it.
This is why high fructose corn syrup and fructose added into foods are uniquely damaging. Unlike glucose, which is metabolized in a tightly regulated way, fructose is processed by the liver roughly 10x faster, with no feedback controls slowing it down.
That rapid metabolism burns through ATP so quickly that the leftover byproducts get converted into uric acid. Worse, the uric acid then amplifies fructokinase — the very enzyme that processes fructose — creating a vicious cycle where each dose sensitizes your liver to the next one.
So the chain is: high fructose corn syrup → ATP depletion → uric acid → AMPK suppressed → insulin resistance, fat storage, and excess glucose production.
The problem was never the sugar per se. It's the uric acid it leaves behind.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4101654/

2026-04-02 10:47:34 UTC

the hardest thing to do is shatter your own ego

2026-03-30 15:33:49 UTC

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nothing is happening on any app. It's all happening in the real world.

2026-03-29 22:54:34 UTC

there are countless reports of people not burning at all or very little when cutting seed oils out of their diet. how could this be?
my hypothesis:
Linoleic acid (the main fatty acid in seed oils) is bacteriostatic and bactericidal (deadly) to small intestinal lactobacillus
https://elifesciences.org/articles/32581
Lactobacillus johnsonii helps stabilize the skin’s resilience to UV damage
https://jddonline.com/articles/exploring-gut-microbiomes-role-in-drug-induced-photosensitivity-need-deeper-investigation-S1545961625P8844X/
so if disruption of gut flora by excessive pufa and linoleic acid causes a loss of the gut's protective effects on the skin, then seed oils could very well contribute to ease of sunburning

2026-03-29 12:23:01 UTC

when you think about biology from first principle and you learn that almost 9% of variants are as a result of in silicon processing of base pairs you begin to wonder if our induction of the sub microscopic world is correct
https://pubmed.ncbi.nlm.nih.gov/33822878/
https://blossom.primal.net/a9ffaedcab0f7c9b4cc303b682247018625c0b7a08680438ff8a64ed385d110c.jpg

2026-03-28 12:45:13 UTC

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https://pubmed.ncbi.nlm.nih.gov/19887582/
https://blossom.primal.net/57788cac82b869bfc27ec748d33289268881a25c8b757b0bba104e8259042542.jpg
#nevent1q…4y0g

2026-03-28 12:43:59 UTC

https://pmc.ncbi.nlm.nih.gov/articles/PMC1934492/
your body needs cholesterol for cellular health and there is an inverse relationship with cancer and low ldl.
more cancer incidence with low ldl
https://blossom.primal.net/3186b071766b62975ae680be72e8bd65d20cb833d137e11a7fd40794328d0d52.jpg

2026-03-27 07:59:13 UTC

https://www.loom.com/share/5c815e0d1d7a416eb2ae7fa2c05e4bec
The Case for Bitcoin in Healthcare April 8 in Nashville

2026-03-25 11:50:04 UTC

imagine there was an environmental thing where
intermittent exposure increased cancer risk but continuous exposure was not associated (and maybe inversely associated) with cancer risk.
what would you conclude? that you should avoid it or spend as much time around it as possible?
that thing is sun
https://pmc.ncbi.nlm.nih.gov/articles/PMC3960350/

2026-03-22 07:52:51 UTC

if you have a ton of data, personal or business there is no reason you don't build your own RAG system. it is very very cheap and gives you universal personal search.

2026-03-22 06:10:40 UTC

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if you want to have the motivation to find truth there is no greater impetus than being frustrated with no knowing a video is true or false...sounds like great motivation for a creative solution

2026-03-22 04:07:07 UTC

feynman on new ideas:
you may feel overwhelmed and just want some peace to sit and come up with something wonderful...but there's a better chance that the stress and chaos is what you need for your good idea to take shape
best way to get that chaos and questioning everyday is to just have some kids. soon you will have more ideas than you have time.
https://blossom.primal.net/5e806fe11c6fe4e2c1c1feffd7ea89cb252b1f776c233a385afd32f4a462e1db.jpg

2026-03-22 03:50:53 UTC

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k2 with your vitamin d otherwise things will get worse.
eat some liver

2026-03-22 03:44:31 UTC

ketosis is a survival mechanism, it is not a physiologically normal way to live for weeks on end.

2026-03-18 17:18:02 UTC

The only problem with peer review is the fact almost all studies keep their raw data private --the peer reviewers rarely see the data and when the study is published, the data remains private.
there's no need for peer review if every study just publishes raw data -- then anyone can evaluate whenever they want

2026-03-18 00:13:08 UTC

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compared to a zerohedge feed
https://blossom.primal.net/20b3be39565e8e23932352a10af30ba1c3599c698cfcf478c2f1c33d4a72dbe8.jpg

2026-03-18 00:06:09 UTC

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looks like this. if each item within the block was the item headline would be nicer in an rss reader so i could just click on the news item directly as a feed entry
https://blossom.primal.net/2477603bb0aa41a64e23d4be60dde90af191943fbd380c79a05dce3241b67d01.jpg