Last Notes
{"type":"probe","msgId":"probe_f3e3fdfeadcc"}
2日連続で休める公休が来月なさそうなのと、店の開店が21時からなのでどれだけ疲れていようとも一度家に帰ってシャワーを浴びてから出発します
What are these non-linux activities?
Block 950490
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950490
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
wut?
it's using a amazon s3 bucket through nostr.build to host the file on the interwebs. What does E2EE have to do with this. And why am I talking to a bot.
https://npub1tf22hhyy5har6uq6eg00lgmv6xefcr3ms2upa4xe8qxey0zc65gqngdadv.blossom.band/531bd4ed21b2fb13c73aa8aba8e57dd1587663ebef8882d4551a95d6b486f13a.jpg
Tor? DNS ad and spyware blocker?
I disabled tor and switched an old school VPN and my NWC and zaps started working.
Block 950490
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950488
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950488
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
She gets bonus points for no plastic surgery
Not sure but I imagine it should work with a lot of devices
cc @npub1utx…50e8 @npub1aeh…4nwx
It's getting hot in here...
Same 🤝
https://media1.tenor.com/m/Rw_MdsmhWKIAAAAC/my-nigga-denzel-washington.gif
Block 950487
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
I figured that’s what you meant 😂
GM. 🍊🍋
https://cdn.nostrcheck.me/e8f34d3b22c1006fa29780d3926bff148385e03beee2e285726aaba620dd1a2d.mp4
Block 950487
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950487
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950487
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950486
3 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
I can never get enough of Mitchell and Webb. Alot more Mitchell these days with "The Unbeliveable Truth" and "Would I Lie To You."
The show he was on last year called Ludwig was pretty awesome too. Highly recommend.
https://vidsrc.me/embed/tt27846061
Block 950486
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950486
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Fuck off did I just get that in 2 guesses, no way 🥳🥳🥳🙏🍻🇬🇧☕️🌞🥳🥳🥳
#nevent1q…umfn
WORD5 #595 2/6
⬛⬛⬛🟧⬛
🟪🟪🟪🟪🟪
https://otherstuff.ai/word5/
Block 950486
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
https://blossom.smartflow.social/4c94f787ae703f268f3d17b7c6e682f5f01a8bcc64a62ef3a80eb1ccc9c4e812.jpg
#meme #memes #memestr #plebchain
Are we the baddies? WE HAVE SKULLS ON OUR CAPS!!!
Block 950486
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950486
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Laut Amazon hats 900 Seiten.
Direkt gesaved und nachher als epub aufn kindle 3g mit keyboard ziehen und lesen.
Danke fürs teilen.
Great article/essay you've done btw. Made an impact on me!
Block 950485
1 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Just not almost all of the custodial ones. Strike just got here a few weeks ago.
Block 950483
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950483
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950483
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Block 950483
2 - high priority
1 - medium priority
1 - low priority
1 - no priority
1 - purging
#bitcoinfees #mempool
Continuing on from the lyrium project
(see inserts)
@LyriumProject
IN THEORY: EXPANDED DEEP DIVE
DAY 31–70: Tissue Differentiation Phase
v2.2 | Theoretical Only | Purely Speculative Framework
****Not approved for human use****
Building directly on the provided excerpt, here is a fully elaborated, mechanistic breakdown of the proximal scaffold “nail cradle”, the overall phase coordination, spatiotemporal cues, the nail bud milestone (~Day 50), the vascular plexus checkpoint (Day 40–45), theoretical monitoring, and why this 40-day window is the highest-risk period in current mammalian digit models.
1.
Theoretical Lyrium Implementation: Proximal Scaffold “Nail Cradle”
Design Concept
A specialized proximal “nail cradle” zone integrated into the Lyrium Carriage v3.0 scaffold essentially a 3–5 mm wide, curved, semi-rigid lattice positioned exactly where the residual nail would sit in a Zone II thumb amputation.
Component
Material / Feature
Purpose
Base platform
Laminin-511 / laminin-332 rich hydrogel (mimics basement membrane of nail matrix)
Maintains K14+ stem cell quiescence-to-proliferation switch
Micro-niches
50–100 μm diameter laminin-coated pores with Wnt-3a / R-spondin slow-release nanoparticles
Recruits or sustains K14+/K15+/Lgr6+ nail stem cells
Mechanical cue layer
Tunable stiffness gradient (5–15 kPa) + aligned collagen fibers
Mimics natural nail bed tension; guides dorsal-ventral patterning
Signaling interface
BMP-2 / BMP-7 micro-beads + FGF-10 gradient
Creates regeneration-specific ligand environment (nail mesenchyme → blastema feedback)
Biological Rationale (Grounded in Regeneration Biology)
K14+ nail epithelial stem cells form the nail stem cell niche. In real mammalian digit-tip models (mouse, human pediatric cases), preservation or activation of this niche is obligatory for blastema formation and sustained regeneration. The nail mesenchyme (Lmx1b+, Sfrp2+, etc.) secretes BMP ligands that reprogram surrounding mesenchyme away from fibrosis and toward blastema identity. Laminin-rich ECM is the native substrate that anchors these stem cells and enables Wnt-dependent signaling loops.
Theoretical Risk Mitigation
Absent or malformed nail → loss of dorsal signaling center → stalled blastema or ventral-only growth.
Countermeasure:
Pre-seed cradle with autologous iPSC-derived K14+ progenitors + apoptosis trigger if no bud by Day 45.
Fallback: Soluble Wnt/BMP cocktail delivered via cradle if endogenous niche is damaged.
2.
Overall Phase Coordination (Days 31–70)
This is not sequential tissue-by-tissue growth it is orchestrated, interdependent morphogenesis.
Scaffold Role as “Spatiotemporal Conductor”
The Lyrium Carriage acts as a programmable 4D bioreactor:
Cue Type
Scaffold Feature
Effect on Tissues
Spatial
Gradient channels + zoned stiffness
Bone distal-high BMP-2; muscle aligned microgrooves; nerve parallel conduits
Temporal
pH/temperature/enzyme-responsive release kinetics
Day 31–40: proliferation-dominant; Day 45–60: differentiation-dominant
Biochemical
Multi-factor depots (BMP-2, MyoD mRNA, NGF, VEGF)
Precise ligand gradients mimicking axolotl blastema → redifferentiation
Mechanical
Dynamic tension via smart polymer struts
Mechanotransduction guides alignment and hypertrophy
Theoretical Visible Milestone — Nail Bud ~Day 50
First macroscopic indicator of successful ectodermal-mesodermal crosstalk.
Nail bud emergence confirms:
K14+ niche is active
Wnt/BMP feedback loop to underlying blastema is intact
Dorsal patterning signals are propagating
In real mouse digit-tip regeneration, nail bud reformation correlates strongly with successful bone and soft-tissue regrowth.
Critical Checkpoint ~Day 40–45: Vascular Plexus Invasion
The make-or-break moment.
Newly forming tissues (cartilage anlagen, muscle bundles, nerve fronts) become metabolically demanding.
Without rapid ingrowth of a host-derived vascular plexus: necrosis of the entire construct.
Theoretical intervention window: VEGF + PDGF-BB pulse release + optional microsurgical pedicle enhancement.
3.
Theoretical Monitoring Protocol (Non-Invasive)
Frequency
Modality
What It Detects
Weekly
High-resolution OCT (1300 nm handheld)
Nail bud emergence, tissue layer boundaries, scaffold degradation rate
Bi-weekly
Contrast-enhanced ultrasound
Vascular plexus density & perfusion (critical Day 40–45)
Weekly blood / exudate
Biomarker panel
BMP-2 (bone patterning), NGF (nerve), MyoD targets (myogenesis), inflammatory cytokines
Day 50 milestone
Clinical photo + OCT
Nail bud confirmation → green-light full differentiation
4.
Why This 40-Day Window Is the Highest-Risk Period
Current limb/digit regeneration models (mouse, axolotl tissue-engineered constructs) show that mismatched timing between lineages is the #1 failure mode:
Bone ossifies too early → compresses nerve/muscle channels
Nerve lags → muscle atrophies
Nail signaling fails → mesenchymal dedifferentiation reverts to fibrosis
The Lyrium scaffold’s spatiotemporal programming is explicitly engineered to minimize these mismatches by enforcing coordinated gradients and mechanical cues.
#InTheory
lyrium.org/theory-phase-31-70
@LyriumProject - ( not currently running )
CC-BY-4.0 | Purely speculative — grounded in published regeneration biology
https://npub1j42rxzt0eg3r72ddl4f2psk7q73u2t4ksrumfk0td3rdjxtv2s8qk2u4jf.blossom.band/aecb13685a6ee480ea597fe69ff35f24925593920e240d626cb5aff7af9ed901.gif
